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Episode 267: Healing Skin from the Inside Out: The Gut-Brain-Skin Connection with Dr. Barbara Paldus

If you’ve ever dealt with stubborn skin issues like I have, you know how frustrating it can be to try product after product, only to end up right back where you started. That’s why I’m so excited about today’s guest, Dr. Barbara Paldus.

She’s not just a skincare founder—she’s a Stanford-trained scientist and biotech powerhouse who’s spent her career solving complex problems, from detecting greenhouse gases to improving vaccine production.

But when her son developed severe allergies to common skincare ingredients, she turned her focus to something much closer to home—our skin.

In 2018, she founded Codex Labs, a science-backed skincare brand that’s redefining how we treat skin concerns by looking at the whole picture: our gut, our brain, and our skin microbiome

Codex is all about clean, clinically proven, plant-based formulas that actually work—and don’t just treat symptoms, but support skin from the inside out.

Today, Dr. Paldus is here to help us make sense of the skin-gut-brain connection, what real innovation in skincare looks like, and how we can better support our bodies to get glowing, healthy skin—without the guesswork.

She’ll be digging into these questions to give us all the clarity we need for clear, beautiful skin: 

  1. For those who are new to this concept, how exactly does the gut and brain influence the skin?
  2. What are some signs that skin issues might actually be rooted in gut health?
  3. Are there any lifestyle or dietary changes you typically recommend for people trying to heal both their gut and skin?
  4. How does Codex Labs incorporate the skin-gut connection into its formulas?
  5. What role do probiotics or prebiotics play—topically and internally—when it comes to restoring balance?
  6. How does Codex Labs integrate biotech solutions into skincare products?
  7. What are some common misconceptions people have about skincare?

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